Which Is More Prominent in Recurrent Hydatidiform Mole, Ovum or Sperm?

Authors

  • Maryam Hafezi Department of Endocrinology and Female Infertility, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran
  • Mohammad Reza Zamanian Department of Genetics, Reproductive Biomedicine Research Center , Royan Institute for Reproductive Biomedicine, ACECR, Tehran , Iran
  • Zahra Chekini Department of Endocrinology and Female Infertility, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran
Abstract:

Recurrent hydatidiform mole is defined as episodes of two molar pregnancies in a female. Often, complete moles onlyderive androgenic nuclear genome. We described two cases with repeated molar pregnancies attempted to preventfuture episodes by performing intracytoplasmic sperm injection (ICSI) and preimplantation genetic diagnosis (PGD)to assess genetic disorders. The first patient had previously six complete molar pregnancies and advised to carry outICSI with ovum donation to achieve a normal pregnancy. The second case had previously five molar pregnancies andno XY embryos from the ICSI/PGD process. We had to (at the insistence of the patient) transfer XX embryos in thispatient which resulted in a complete hydatidiform mole (CHM). Hence, available data based on our patients and previousstudies demonstrated that oocyte might play a critical role in the pathophysiology of recurrent hydatidiform mole,while it has not been often considered.

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Journal title

volume 14  issue 2

pages  154- 158

publication date 2020-07-01

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